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Liraglutide Effect in Atrial Fibrillation

January 24, 2020


The goal of this study is to use a medication called Liraglutide to reduce fat deposits surrounding the heart, and to possibly reduce atrial fibrillation activity. Patients will take the medication and participate in a weight management and exercise program for 30 minutes, 2 to 4 times a week. Patients will also undergo lifestyle changes if necessary, including hyperlipidemia management, management of obstructive sleep apnea, management of hypertension, diabetes management, smoking cessation, and alcohol abstinence or reduction.


Study Information

60 subjects will be enrolled in the study. The primary purpose of the trial is treatment. The study began on March 18, 2018 and is estimated to be completed by December 31, 2022.


Inclusion Criteria


  • Male and female, age 18 or older
  • Persistent atrial fibrillation defined as continuous AF that is sustained beyond 7 days (or atrial fibrillation in which a decision is made to cardiovert the patient prior to 7 days).
  • BMI ≥27 kg/m2
  • Patient wishes to undergo catheter ablation procedure for treatment of atrial fibrillation
  • Receiving follow-up care at the University of Miami


Exclusion Criteria


  • Inability to sign informed consent
  • Patients with paroxysmal atrial fibrillation and longstanding persistent atrial fibrillation
  • Prior ablation for atrial fibrillation
  • Patients not appropriate candidates for catheter ablation such as those with AF due to acute or chronic precipitating medical conditions, for example hypothyroidism and hyperthyroidism, significant pulmonary disease, pulmonary embolism, left atrial thrombus, class IV heart failure)
  • Patients with a life expectancy <1 year
  • Patients with a serious medical condition (for example, recent cancer with chemotherapy or radiation therapy within 4 weeks prior to entering the study) who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
  • Known contraindications to Liraglutide, such as previous history of pancreatitis or medullary thyroid carcinoma
  • Personal or family history of multiple endocrine neoplasia
  • Known serious hypersensitivity reaction to Liraglutide
  • Patients using insulin, sulfonylureas, glitazones, sodium-glucose transporters 2 inhibitors (SGLT2i), other Glucagon-like peptide analogues or dipeptidyl peptidase 4 inhibitors
  • Type 1 diabetes, defined by American Diabetes Association criteria, history of diabetic ketoacidosis, pancreas or beta-cell transplantation, or diabetes due to pancreatitis or pancreatectomy
  • Pregnant women
  • Women who are breast-feeding or intend to become pregnant



The study will take place at the University of Miami, Miami, Florida, United States, 33136. If you have any questions, please contact Carmen Baez-Garcia, RN at 305-243-3845 / or Barbara Lang, RN at 305-243-3845 /


Sponsors / Collaborators

The study is sponsored by the University of Miami. The principal investigator is Jeffery Goldberger, MD of the University of Miami.

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