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Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation

January 24, 2020


The goal of this study is to see how electrogram morphology recurrence (EMR) mapping works on patients with atrial fibrillation, in order to pinpoint areas of high EMR rate. The study will help determine if this technology is able to terminate or slow atrial fibrillation. The investigator will use EMR mapping on the patients’ atrial fibrillation to indicate locations of stable activity and ablate the area.


Study Information

10 subjects will be enrolled in the study. The primary purpose of the trial is treatment. The study began on April 4, 2017 and is estimated to be completed by December 31, 2020.


Inclusion Criteria


  • Men and women of at least 21 years of age
  • Persistent atrial fibrillation (AF) with one prior failed ablation for persistent or long standing persistent AF.


Exclusion Criteria


  • Inability to sign consent
  • Patients with a life expectancy less than one year
  • Patients with chronic kidney disease with sufficiently low GFR that precludes either CT angiogram of the heart or contrast MRI study
  • Pregnant women and women that are breastfeeding
  • Patients with multiple (2 or more) prior failed ablations
  • Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.



The study will take place at the University of Miami, Miami, Florida, United States, 33136. If you have any questions, please contact Raul Mitrani, MD at 305-243-5070 /


Sponsors / Collaborators

The study is sponsored by Jeffery Goldberger of the National Heart, Lung, and Blood Institute (NHLBI). The principal investigator is Raul Mitrani, MD of the University of Miami.

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