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Oral vs Intravenous Diltiazem for Rapid Atrial Fibrillation/Flutter

January 24, 2020


The goal of this study is to compare heart rate control (heart rate <110 beats per minute) at 2 hours after taking the medication diltiazem orally vs. intravenously. Diltiazem is a non-dihydropyridine calcium channel blocker medication used to manage atrial fibrillation. Patients will receive either an oral dose or intravenous dose of diltiazem and their heart rates will be monitored. Incidence of adverse events will be logged as well (heart rate <60 beats per minute, systolic blood pressure <90 mmHg requiring intervention).


Study Information

320 subjects will be enrolled in the study. The primary purpose of the trial is treatment. The study began on June 1, 2018 and is estimated to be completed by March 2021.


Inclusion Criteria


  • >/= 18 years old
  • Atrial fibrillation or flutter on electrocardiogram
  • Heart rate >110 beats/min
  • Systolic blood pressure >/= 90 mmHg


Exclusion Criteria


  • Limited English proficiency (LEP)
  • Pregnant
  • Prisoners
  • Wolff Parkinson White syndrome
  • Administration of electrical or chemical cardioversion before screening
  • Administration of other antiarrhythmics for acute heart rate control (excluding adenosine)
  • History of allergy or idiosyncratic reaction to diltiazem
  • Unable to take oral medications
  • Heart rate <60 beats/min



The study will take place at Virginia Commonwealth University, Richmond, Virginia, United States, 23298. If you have any questions, please contact Tammy T Nguyen, PharmD, BCPS at 804-663-0969 /


Sponsors / Collaborators

This study is sponsored by Virginia Commonwealth University. The principal investigator is Tammy T Nguyen, PharmD, BCPS of Virginia Commonwealth University.

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